Psilocybin Laws in Missouri
Psilocybin is illegal in Missouri with no active legislation. Missouri legalized recreational cannabis via ballot initiative in 2022, and advocates are exploring whether a similar path is viable for psilocybin.
Current Legal Status
Illegal — No Active Legislation
Psilocybin is a Schedule I controlled substance under Missouri law. Possession is a Class D felony for small amounts. No Missouri city has passed a decriminalization resolution.
Key Legislation
No psilocybin legislation has been introduced in the Missouri General Assembly, though cannabis legalization (Amendment 3, 2022) demonstrates the ballot initiative pathway.
Clinical Trials
Washington University in St. Louis has participated in psychedelic research. Check ClinicalTrials.gov for St. Louis and Kansas City area enrolling studies.
Advocacy Organizations
Show-Me Psychedelics, Healing Advocacy Fund.
Related Resources
See how Missouri compares to neighboring states and find therapy options for residents: