Psilocybin Laws in Colorado
Colorado voters passed Proposition 122 in November 2022, creating the most permissive psilocybin framework in the US. Adults 21+ may grow, possess, and share psilocybin mushrooms privately, and licensed healing centers began operating in 2024.
Current Legal Status
Legal Healing Centers + Personal Use Decriminalized
Colorado has a two-track system. Personal use: adults 21+ may possess, grow, and share (not sell) psilocybin for personal use. Licensed healing centers: facilitators — who may be licensed mental health professionals — provide supervised sessions, which may integrate with psychotherapy and may occur at licensed centers or private residences.
Key Legislation
Proposition 122 (2022) — the Natural Medicine Health Act — decriminalized personal adult use and created the healing center framework. DORA oversees licensing. Denver was the first US city to decriminalize psilocybin at the municipal level (May 2019), two years before the state program.
Therapeutic Programs
Colorado healing centers are DORA-licensed. Unlike Oregon, facilitators may be licensed mental health professionals and can integrate psilocybin with psychotherapy. Sessions may also occur at private residences with regulatory approval.
Decriminalization
Personal adult possession, cultivation, and gifting (non-commercial) of psilocybin mushrooms is decriminalized statewide for adults 21+.
Clinical Trials
University of Colorado Boulder and COMPASS Pathways have conducted Colorado-based psilocybin research. Active studies underway — check ClinicalTrials.gov.
Advocacy Organizations
Natural Medicine Colorado, Healing Advocacy Fund, Colorado Healing Alliance, DORA (regulatory body).
Related Resources
Directory in Colorado
- SANCTUM — Colorado Healing Center
- Center Origin — Colorado Healing Center
- ETC Hospitality Center — Colorado Healing Center
- Happy Rebel Healing — Colorado Healing Center
- Innate Path — Colorado Healing Center
- Colorado Psychedelic Church / PACK Life — Sacramental Church
- Sage & Stone Healing — Colorado Healing Center
- Sage Psychedelic Institute — Colorado Healing Center
- Iron Horse Healing — Colorado Healing Center
- Peak States Wellness — Colorado Healing Center
- Roots to Rise Ketamine and Integration Therapy — Therapy Clinic
View all Colorado directory listings →
People in Colorado
- Teopixqui Dez — Founder & Spiritual Director, Colorado Psychedelic Church / PACK Life
- Lorey Bratten — Director, Colorado Natural Medicine Advisory Board
- Dr. Sue Sisley — Medical Researcher; Colorado Natural Medicine Advisory Board Member
- Dan Engle, M.D. — Psychiatrist; Psychedelic-Assisted Therapy Practitioner; Author
Societies & Organizations in Colorado
- Psychedelic Club of Denver (PCoD) — Community Society
- Colorado Mycological Society — Mycology Club
- The Nowak Society — Professional Network
- Colorado Psychedelic Society — Community Group
- Colorado Veterans Natural Medicine Alliance — Veterans Advocacy
See how Colorado compares to neighboring states and find therapy options for residents: