Psilocybin Laws in South Carolina
Psilocybin is illegal in South Carolina with no active legislation. South Carolina has conservative drug laws and has not moved toward cannabis legalization.
Current Legal Status
Illegal — No Active Legislation
Psilocybin is a Schedule I controlled substance under South Carolina law. Possession is a misdemeanor for first offense; distribution is a felony.



Key Legislation
No psilocybin legislation has been introduced in the South Carolina General Assembly.
Clinical Trials
Medical University of South Carolina (MUSC) in Charleston has conducted MDMA and psilocybin research. Check ClinicalTrials.gov for Charleston-area enrolling studies.
Advocacy Organizations
No South Carolina-specific psychedelic advocacy organizations are currently active. MUSC researchers are active in national psychedelic research networks.
Related Resources
People in South Carolina
- Michael Mithoefer, M.D. — Psychiatrist; Lead MDMA-PTSD Researcher; MAPS Medical Director
- Annie Mithoefer — Psychiatric Nurse; MDMA-Assisted Therapy Co-Therapist; MAPS Trainer
See how South Carolina compares to neighboring states and find therapy options for residents: