Illegal — No Active Legislation
Updated 2026-04-20
Psilocybin Laws in Mississippi
Psilocybin is illegal in Mississippi with no active legislation. Mississippi has among the most conservative drug laws in the US and has only recently adopted limited medical cannabis.
Current Legal Status
Illegal — No Active Legislation
Psilocybin is a Schedule I controlled substance under Mississippi law. Possession carries felony charges; distribution penalties are severe.
Key Legislation
No psilocybin legislation has been introduced in the Mississippi Legislature.
Clinical Trials
University of Mississippi has a long history of federally licensed drug research. Check ClinicalTrials.gov for enrolling psilocybin studies in Mississippi.
Advocacy Organizations
No Mississippi-specific psychedelic advocacy organizations are currently active.
Related Resources
See how Mississippi compares to neighboring states and find therapy options for residents: