Microdose Stack Protocols Compared: Fadiman vs Stamets vs Day-On-Day-Off

Fadiman protocol (1 day on, 2 days off): the original and most studied. The off days prevent tolerance accumulation and are described by Fadiman as equally important as dose days — integration days. Most clinical self-report research uses this protocol. Best for: general well-being, mood, productivity. Duration: most people run 4-8 week blocks, then take 2-4 weeks off completely.

Stamets stack (4 days on, 3 days off with lion's mane + niacin): the rationale is that lion's mane (hericenones/erinacines) synergizes with psilocybin for neurogenesis, and niacin as a flushing agent aids distribution. The scientific basis for the specific combination is largely theoretical — the human RCT data on this exact stack doesn't exist yet. Experientially, many find it more cognitively activating than psilocybin alone. Anecdotally reported to be better for neurological applications.

Every-other-day (Day On/Off): higher effective weekly dose than Fadiman, more likely to produce tolerance with sustained use. Some people find the more frequent dosing produces a more consistent baseline effect. Not recommended for sustained periods — most practitioners suggest 4-6 weeks max before a full break. Better for acute situations (targeted short course) than long-term lifestyle integration.