Psilocybin and gut health -- the gut-brain connection in psychedelic therapy
198 replies · Science
Since psilocybin acts on serotonin receptors, and 90% of serotonin is in the GI tract, I'm curious whether there's any research on its effects on gut health or microbiome beyond just the nausea question.
Early-stage research, mostly preclinical. The 5-HT4 receptors in the gut influence motility and secretion; 5-HT3 receptor activity drives the nausea. Some animal studies suggest altered gut microbiome composition after psychedelic exposure, but direct human data is limited.
Anecdotally: I have IBS and have noticed that for a few weeks after psilocybin sessions my gut is significantly calmer. Less reactivity to foods that normally trigger me. I track this carefully because it's motivated my continued use as much as the mental health benefits.
One practical note: fasting 4-6 hours before a session is standard advice for nausea reduction. There's also evidence that the vagal response to an empty stomach may enhance psychedelic effects slightly.
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