Colorado Prop 122 — how is it different from Oregon's model?
44 replies · Legal & Policy
I understand Colorado passed Proposition 122 in 2022 and started the licensing process. How does the Colorado model differ from Oregon? Is there anything it does better or worse? And is it actually operational or still in the licensing phase?
Key differences from Oregon:
1. Colorado legalized five substances, not just psilocybin: psilocybin, psilocin, DMT, ibogaine, and mescaline (not peyote). Oregon is psilocybin only.
2. Colorado's model includes 'healing centers' (equivalent to Oregon's service centers) but also allows facilitators to eventually provide services at private residences, subject to state regulation — Oregon is licensed facilities only.
3. Colorado has a 'social equity' fund built into the framework from inception — 15% of licensing fees go to equity programs. Oregon added equity provisions later.
Operational status as of mid-2026: Colorado's licensing program became operational for training programs in late 2024 and began licensing healing centers in 2025. There are active licensed facilities in Denver, Boulder, and Fort Collins. The program is smaller than Oregon's (fewer licensed centers) but growing rapidly.
The multi-substance scope is both Colorado's most innovative and most complex aspect. Ibogaine in particular has a very different safety profile from psilocybin — cardiac risks that require medical screening. How Colorado manages medical oversight for ibogaine-qualified facilitators vs. psilocybin-only facilitators is still being worked out in practice.
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