If you had 10 minutes with a psilocybin researcher, what would you ask?

I'd ask: what do you personally believe psilocybin is doing — mechanistically, psychologically, philosophically? Not what the data says, but what you think is actually happening. The published literature is careful and measured. I want to know what someone who has spent 20 years studying this actually believes, in the moments when they're not writing for peer review.

My question: why does the mystical experience predict outcomes so strongly across conditions as different as depression, addiction, and cancer anxiety? Is there something specific about the nature of mystical experience that's therapeutic, or is mystical experience just a proxy for how strong was the session? I've never found this fully answered.

Practical one: what do you tell people who come to you having already had multiple high-dose experiences without integration and who haven't benefited — or who feel worse? The literature covers naive subjects in controlled settings. What happens with the long-term psychedelic user who isn't getting what they hoped for?